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KMID : 0383419680090020189
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Korean Modern Medical Journal
1968 Volume.9 No. 2 p.189 ~ p.192
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The Effect of 2-Mercapto-Ethanol(2ME) on Serum Gamma-Globulin
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李能姬/Lee, Nung Hee
朴英淑/獨孤英昌/金世坤/Park, Young Sook/Tocko, Young Chang/Kim, Se Kon
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Abstract
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The effect of 2-Mercapto-Ethanol(2ME) on serum gamma globulin of 2months to 15months o age was experimented by hemagglutination-inhibition (H-I) antibody titration against Japanese . encephalitis virus(J.E.V). Gamma globulin is divided to 19 S & 7 S gamma globulin by their molecular weight (19 S: 900, 000^-1, 000, 000, 7S: 150, 000)- Immunologically, 7 S gamma globulin is more significant which has permanent antibody than 19 S gamma globulin which has temporal antibody only. Right after vaccination or infection, 19 S gamma globulin aFFears for 1-x-3 weeks followed by 7`S gamma globulin or Permanent antibody appearance. 2 ME irzctivates 19 S gamma globulin dropping the antibody titer. The serum gammaglobulin which contains higher 7S gamma globulin was less inactivated by 2 ME. This, we may call 2 ME resistant, on the contrary the serum contains higher 19 S gamma globulin was more inactivated and we may call as ISME sensitive. From the experiment the transmission from 2ME resistant to 2ME sensitive, seemed to be 5months of age. In other words, maternal serum gamma globulin, especially 7 S gamma globulin which is 2ME resistant and immunologically significant starts to drop the antibody titer at 5 months of age.
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KEYWORD
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